{"id":1968,"date":"2024-12-14T09:00:03","date_gmt":"2024-12-14T05:30:03","guid":{"rendered":"https:\/\/www.rtzco.com\/?p=1968"},"modified":"2025-01-05T08:42:54","modified_gmt":"2025-01-05T05:12:54","slug":"%d9%85%d9%87%d8%a7%d8%b1-%d9%84%db%8c%d9%be%d9%88%d9%84%db%8c%d8%b2-%d8%a8%d9%87-%d8%b9%d9%86%d9%88%d8%a7%d9%86-%d8%af%d8%b1%d9%85%d8%a7%d9%86-%da%a9%d8%aa%d9%88%d8%b2-%d8%a8%d8%a7%d9%84%db%8c%d9%86","status":"publish","type":"post","link":"https:\/\/www.rtzco.com\/de\/2024\/12\/14\/%d9%85%d9%87%d8%a7%d8%b1-%d9%84%db%8c%d9%be%d9%88%d9%84%db%8c%d8%b2-%d8%a8%d9%87-%d8%b9%d9%86%d9%88%d8%a7%d9%86-%d8%af%d8%b1%d9%85%d8%a7%d9%86-%da%a9%d8%aa%d9%88%d8%b2-%d8%a8%d8%a7%d9%84%db%8c%d9%86\/","title":{"rendered":"Hemmung der Lipolyse zur Behandlung der klinischen Ketose bei Milchk\u00fchen"},"content":{"rendered":"
\"\"<\/figure>

Eine \u00fcberm\u00e4\u00dfige und anhaltende Lipolyse im Fettgewebe von Milchk\u00fchen ist ein Hauptrisikofaktor f\u00fcr die klinische Ketose (CK). Diese Stoffwechselerkrankung tritt h\u00e4ufig bei postpartalen K\u00fchen auf, wenn die Fetts\u00e4urelipolyse als Energiesubstrat genutzt wird, um eine negative Energiebilanz auszugleichen. Die Lipolyse bei Rindern kann sowohl auf konventionellen (hormoninduzierten) als auch auf entz\u00fcndlichen Wegen induziert werden.\nAktuelle Behandlungen f\u00fcr CK konzentrieren sich auf die Verbesserung des Blutzuckers (z. B. orales Propylenglykol [PG] oder (i.v.) Dextrose). Diese Behandlungen hemmen jedoch nicht die herk\u00f6mmlichen lipolytischen und entz\u00fcndlichen Wege. Niacin (NIA) kann die Aktivierung des kanonischen Signalwegs reduzieren.\nDie Blockierung entz\u00fcndlicher Reaktionen mit Cyclooxygenase-Inhibitoren wie Flunixin-Meglumin (FM) kann die entz\u00fcndliche lipolytische Aktivit\u00e4t hemmen. Ziel dieser Studie war es, die Auswirkungen von NIA und FM in der Standardbehandlung mit Propylenglykol bei postpartaler klinischer Ketose auf die Ketonk\u00f6rperkonzentrationen zu bestimmen.<\/p>

Eine Studie (randomisiert in 4 Gruppen, parallel und getrennt an mehreren Jersey-K\u00fchen (80 St\u00fcck)) wurde \u00fcber einen Zeitraum von 7 Monaten in einem industriellen Milchviehbetrieb durchgef\u00fchrt. Geeignete K\u00fche, Anzeichen einer klinischen Ketose (Lethargie, verminderter Appetit und verminderte Milchproduktion) und Hyperketon\u00e4mie (\u03b2-Hydroxybutyrat [BHB] im Blut \u2265 1,2 mmol\/l) hatteK\u00fche mit klinischer Ketose wurden nach dem Zufallsprinzip einer von drei Gruppen zugeordnet, wobei die erste Gruppe 5 Tage lang einmal t\u00e4glich 310 g PG erhielt, die zweite Gruppe 5 Tage lang PG und 3 Tage lang einmal t\u00e4glich 24 g NIA oral erhielt Die dritte Gruppe erhielt 5 Tage lang PG plus 3 Tage lang NIA + 1,1 mg\/kg, intraven\u00f6ses FM, einmal t\u00e4glich \u00fcber 3 Tage (PGNIAFM) erhalten.Die Kontrollgruppe umfasste K\u00fche, die klinisch gesund waren (HC; keine Behandlung; BHB <1,2 mmol\/L, 27 K\u00fche) und hinsichtlich Abdomen und Laktationstagen allen drei Gruppen zugeordnet waren. Den K\u00fchen wurden am Starttag (Tag 0), 3, 7 und 14 Proben entnommen, um Ketonk\u00f6rper sowie metabolische und entz\u00fcndliche Biomarker im Blut zu bewerten. Die Auswirkungen der Behandlung, des Probenahmetages und deren Wechselwirkungen wurden mithilfe von Mixed-Effects-Modellen bewertet. Die logistische Regression wurde verwendet, um das Odds Ratio (OR) f\u00fcr eine R\u00fcckkehr zur Normokton\u00e4mie (BHB <1,2 mmol\/l) zu berechnen.<\/p>

\"\"<\/figure><\/div>

Im Vergleich zur Kontrollgruppe zeigten K\u00fche mit klinischer Ketose niedrigere Blutkonzentrationen von Dyslipid\u00e4mie-Markern, einschlie\u00dflich nicht veresterter Fetts\u00e4uren (NEFA) und BHB, sowie niedrigere Glukose- und Insulinspiegel. K\u00fche mit klinischer Ketose weisen auch erh\u00f6hte Werte von Biomarkern f\u00fcr Schmerzen und Entz\u00fcndungen auf, darunter Serum-Lipopolysaccharid-bindendes Protein, Haptoglobin und Amyloid A sowie proinflammatorische Zytokine IL-4, MCP-1, MIP-1\u03b1 und TNF\u03b1. Wichtig ist, dass 72,2 % der CK-K\u00fche endotox\u00e4misch waren und im Vergleich zur Kontrollgruppe mehr zirkulierende Bakterien-DNA aufwiesen. Am 7. Tag lag der h\u00f6chste Prozentsatz an K\u00fchen mit Normokton\u00e4mie bei PGNIAFM = 87,5 %, verglichen mit PG = 58,33 % und PGNIA = 62,5 %. Am 7. Tag betrugen die ORs f\u00fcr Normokton\u00e4mie bei PGNIAFM-K\u00fchen 1,5 bzw. 1,4 im Vergleich zu PG und PGNIA. An den Tagen 3, 7 und 14 hatten PGNIAFM-K\u00fche die niedrigsten Werte von BHB (PG = 1,36; PGNIA = 1,24; PGNIAFM = 0,13 \u00b1 0,89 mmol\/L), NEFA (PG = 0,58; PGNIA = 0,59; PGNIAFM = 0,02). mmol\/L) und pr\u00e4sentierte Akute-Phase-Proteine. K\u00fche, die PGNIAFM erhielten, zeigten auch die h\u00f6chsten Blutzuckeranstiege \u00fcber alle Zeitpunkte hinweg und den h\u00f6chsten Insulinspiegel am 7.<\/p>

Diese Daten liefern Hinweise darauf, dass Bakteri\u00e4mie oder Endotox\u00e4mie, systemische Entz\u00fcndungen und Schmerzen eine wichtige Rolle bei der Pathogenese der klinischen Ketose spielen k\u00f6nnen. Dar\u00fcber hinaus werden Lipolyse und Entz\u00fcndungen gezielt bek\u00e4mpft <\/strong>NIA<\/strong> \u0648 <\/strong>FM<\/strong> .<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

Eine \u00fcberm\u00e4\u00dfige und anhaltende Lipolyse im Fettgewebe von Milchk\u00fchen ist ein Hauptrisikofaktor f\u00fcr die klinische Ketose (CK). <\/p>","protected":false},"author":1,"featured_media":1969,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,9,10],"tags":[],"class_list":["post-1968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1","category-animal-articles","category-poultry-articles"],"acf":[],"yoast_head":"\n\u0645\u0647\u0627\u0631 \u0644\u06cc\u067e\u0648\u0644\u06cc\u0632 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u062f\u0631\u0645\u0627\u0646 \u06a9\u062a\u0648\u0632 \u0628\u0627\u0644\u06cc\u0646\u06cc \u062f\u0631 \u06af\u0627\u0648\u0647\u0627\u06cc \u0634\u06cc\u0631\u06cc | \u0634\u0631\u06a9\u062a \u0631\u0634\u062f \u0637\u06cc\u0648\u0631 \u0632\u0648\u0627\u0631\u0647<\/title>\n<meta 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