{"id":1968,"date":"2024-12-14T09:00:03","date_gmt":"2024-12-14T05:30:03","guid":{"rendered":"https:\/\/www.rtzco.com\/?p=1968"},"modified":"2025-01-05T08:42:54","modified_gmt":"2025-01-05T05:12:54","slug":"%d9%85%d9%87%d8%a7%d8%b1-%d9%84%db%8c%d9%be%d9%88%d9%84%db%8c%d8%b2-%d8%a8%d9%87-%d8%b9%d9%86%d9%88%d8%a7%d9%86-%d8%af%d8%b1%d9%85%d8%a7%d9%86-%da%a9%d8%aa%d9%88%d8%b2-%d8%a8%d8%a7%d9%84%db%8c%d9%86","status":"publish","type":"post","link":"https:\/\/www.rtzco.com\/tr\/2024\/12\/14\/%d9%85%d9%87%d8%a7%d8%b1-%d9%84%db%8c%d9%be%d9%88%d9%84%db%8c%d8%b2-%d8%a8%d9%87-%d8%b9%d9%86%d9%88%d8%a7%d9%86-%d8%af%d8%b1%d9%85%d8%a7%d9%86-%da%a9%d8%aa%d9%88%d8%b2-%d8%a8%d8%a7%d9%84%db%8c%d9%86\/","title":{"rendered":"S\u00fct ineklerinde klinik ketoz tedavisinde lipolizin inhibisyonu"},"content":{"rendered":"
\"\"<\/figure>

S\u00fct ineklerinin ya\u011f dokusundaki a\u015f\u0131r\u0131 ve uzun s\u00fcreli lipoliz, klinik ketozis (CK) i\u00e7in \u00f6nemli bir risk fakt\u00f6r\u00fcd\u00fcr. Bu metabolik hastal\u0131k, negatif enerji dengesini telafi etmek i\u00e7in bir enerji substrat\u0131 olarak ya\u011f asidi lipolizi kullan\u0131ld\u0131\u011f\u0131nda do\u011fum sonras\u0131 ineklerde yayg\u0131nd\u0131r. S\u0131\u011f\u0131rlarda lipoliz hem konvansiyonel (hormon kaynakl\u0131) hem de inflamatuar yollardan tetiklenebilir.\nCK i\u00e7in mevcut tedaviler kan \u015fekerini iyile\u015ftirmeye odaklan\u0131r (\u00f6rne\u011fin, oral propilen glikol [PG] veya (i.v.) dekstroz). Ancak bu tedaviler geleneksel lipolitik ve inflamatuar yollar\u0131 engellemez. Niasin (NIA) kanonik yolun aktivasyonunu azaltabilir.\nFluniksin meglumin (FM) gibi siklooksijenaz inhibit\u00f6rleriyle inflamatuar yan\u0131tlar\u0131n bloke edilmesi, inflamatuar lipolitik aktiviteyi inhibe edebilir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, do\u011fum sonras\u0131 klinik ketozis i\u00e7in standart propilen glikol tedavisindeki NIA ve FM'nin keton v\u00fccut konsantrasyonlar\u0131 \u00fczerindeki etkilerini belirlemektir.<\/p>

End\u00fcstriyel bir s\u00fct \u00e7iftli\u011finde 7 ayl\u0131k bir s\u00fcre boyunca birden fazla Jersey ine\u011fi (80 ba\u015f) \u00fczerinde paralel ve ayr\u0131 olarak 4 gruba randomize edilmi\u015f bir \u00e7al\u0131\u015fma ger\u00e7ekle\u015ftirildi. Uygun inekler, klinik ketoz belirtileri (uyu\u015fukluk, i\u015ftah azalmas\u0131 ve s\u00fct \u00fcretimi) ve hiperketonemi (kan \u03b2-hidroksibutirat [BHB] \u22651,2 mmol\/L) vard\u0131Klinik ketozisli inekler rastgele \u00fc\u00e7 gruptan birine atand\u0131; birinci grup 5 g\u00fcn boyunca g\u00fcnde bir kez oral olarak 310 g PG ald\u0131, ikinci grup 5 g\u00fcn boyunca PG art\u0131 g\u00fcnde bir kez 24 g NIA ald\u0131. \u00fc\u00e7\u00fcnc\u00fc gruba ise 5 g\u00fcn boyunca PG art\u0131 3 g\u00fcn boyunca NIA + 3 g\u00fcn boyunca g\u00fcnde bir kez 1,1 mg\/kg intraven\u00f6z FM verildi. (PGNIAFM) al\u0131nd\u0131.Kontrol grubu, klinik olarak sa\u011fl\u0131kl\u0131 (HC; tedavi yok; BHB <1.2 mmol\/L, 27 inek) ve kar\u0131n ve laktasyon g\u00fcnleri a\u00e7\u0131s\u0131ndan her 3 grupla e\u015fle\u015fen inekleri i\u00e7eriyordu. Kandaki keton cisimlerini ve metabolik ve inflamatuar biyobelirte\u00e7leri de\u011ferlendirmek i\u00e7in ba\u015flang\u0131\u00e7 \u200b\u200bg\u00fcn\u00fcnde (d 0), 3, 7 ve 14'te ineklerden numune al\u0131nd\u0131. \u0130\u015flemin etkileri, \u00f6rnekleme g\u00fcn\u00fc ve bunlar\u0131n etkile\u015fimleri, karma etki modelleri kullan\u0131larak de\u011ferlendirildi. Normoktonemiye (BHB <1,2 mmol\/L) d\u00f6nme olas\u0131l\u0131k oran\u0131n\u0131 (OR) hesaplamak i\u00e7in lojistik regresyon kullan\u0131ld\u0131.<\/p>

\"\"<\/figure><\/div>

Kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, klinik ketozisli inekler, esterle\u015fmemi\u015f ya\u011f asitleri (NEFA) ve BHB dahil olmak \u00fczere dislipidemi belirte\u00e7lerinin kan konsantrasyonlar\u0131n\u0131n daha d\u00fc\u015f\u00fck oldu\u011funu ve daha d\u00fc\u015f\u00fck glikoz ve ins\u00fclin seviyelerini g\u00f6sterdi. Klinik ketozisli ineklerde ayr\u0131ca serum lipopolisakkarit ba\u011flay\u0131c\u0131 protein, haptoglobin ve amiloid A ve proinflamatuar sitokinler IL-4, MCP-1, MIP-1\u03b1 ve TNFa dahil olmak \u00fczere a\u011fr\u0131 ve inflamasyona ili\u015fkin biyobelirte\u00e7lerin seviyelerinde art\u0131\u015f vard\u0131. Daha da \u00f6nemlisi, CK ineklerinin ,2'si endotoksemikti ve kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda dola\u015f\u0131mdaki bakteri DNA's\u0131 daha y\u00fcksekti. 7. g\u00fcnde, normoktonemili ineklerin en y\u00fcksek y\u00fczdesi PGNIAFM = ,5 iken, PG = ,33 ve PGNIA = ,5 idi. 7. g\u00fcnde, PGNIAFM ineklerinde normoktonemi i\u00e7in OR'ler, PG ve PGNIA'ya g\u00f6re s\u0131ras\u0131yla 1,5 ve 1,4 idi. 3, 7 ve 14. g\u00fcnlerde, PGNIAFM inekleri en d\u00fc\u015f\u00fck BHB (PG = 1,36; PGNIA = 1,24; PGNIAFM = 0,13 \u00b1 0,89 mmol\/L), NEFA (PG = 0,58; PGNIA = 0,59; PGNIAFM = 0,02) de\u011ferlerine sahipti. mmol\/L) ve akut faz proteinlerini sundu. PGNIAFM alan inekler ayr\u0131ca 7. g\u00fcnde zaman noktalar\u0131nda ve ins\u00fclinde en y\u00fcksek kan \u015fekeri art\u0131\u015f\u0131n\u0131 g\u00f6sterdi.<\/p>

Bu veriler bakteriyemi veya endotokseminin, sistemik inflamasyonun ve a\u011fr\u0131n\u0131n klinik ketozun patogenezinde \u00f6nemli bir rol oynayabilece\u011fine dair kan\u0131t sa\u011flar. Ayr\u0131ca lipoliz ve inflamasyonun hedeflenmesi <\/strong>B\u0130Z\u0130M<\/strong> Ve <\/strong>FM<\/strong> .<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

S\u00fct ineklerinin ya\u011f dokusundaki a\u015f\u0131r\u0131 ve uzun s\u00fcreli lipoliz, klinik ketozis (CK) i\u00e7in \u00f6nemli bir risk fakt\u00f6r\u00fcd\u00fcr. <\/p>","protected":false},"author":1,"featured_media":1969,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,9,10],"tags":[],"class_list":["post-1968","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1","category-animal-articles","category-poultry-articles"],"acf":[],"yoast_head":"\n\u0645\u0647\u0627\u0631 \u0644\u06cc\u067e\u0648\u0644\u06cc\u0632 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u062f\u0631\u0645\u0627\u0646 \u06a9\u062a\u0648\u0632 \u0628\u0627\u0644\u06cc\u0646\u06cc \u062f\u0631 \u06af\u0627\u0648\u0647\u0627\u06cc \u0634\u06cc\u0631\u06cc | \u0634\u0631\u06a9\u062a \u0631\u0634\u062f \u0637\u06cc\u0648\u0631 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