{"id":2014,"date":"2025-01-04T16:01:43","date_gmt":"2025-01-04T12:31:43","guid":{"rendered":"https:\/\/www.rtzco.com\/?p=2014"},"modified":"2025-01-05T08:54:07","modified_gmt":"2025-01-05T05:24:07","slug":"%d9%86%d9%82%d8%b4-%d8%b3%d9%84%d9%86%db%8c%d9%88%d9%85-%d9%88-%d9%88%db%8c%d8%aa%d8%a7%d9%85%db%8c%d9%86-%d9%87%d8%a7%db%8c-e-%d9%88-b9-%d8%af%d8%b1-%da%a9%d8%a7%d9%87%d8%b4-%d9%88%d8%b1%d9%85-%d9%be","status":"publish","type":"post","link":"https:\/\/www.rtzco.com\/tr\/2025\/01\/04\/%d9%86%d9%82%d8%b4-%d8%b3%d9%84%d9%86%db%8c%d9%88%d9%85-%d9%88-%d9%88%db%8c%d8%aa%d8%a7%d9%85%db%8c%d9%86-%d9%87%d8%a7%db%8c-e-%d9%88-b9-%d8%af%d8%b1-%da%a9%d8%a7%d9%87%d8%b4-%d9%88%d8%b1%d9%85-%d9%be\/","title":{"rendered":"Do\u011fum sonras\u0131 d\u00f6nemde s\u0131\u011f\u0131r mastitisinin azalt\u0131lmas\u0131nda selenyum ile E ve B9 vitaminlerinin rol\u00fc"},"content":{"rendered":"
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Mastitis (meme bezinin iltihab\u0131), s\u00fct ineklerinde genellikle fizyolojik ve hormonal de\u011fi\u015fiklikler ve \u015fiddetli negatif enerji dengesinin ard\u0131ndan oksidatif stresin ya\u015fand\u0131\u011f\u0131 do\u011fum sonras\u0131 d\u00f6nemde (ge\u00e7i\u015f d\u00f6nemi) meydana gelir. Ba\u015far\u0131l\u0131 emzirmeyi s\u00fcrd\u00fcrmek ve negatif enerji dengesiyle (NEB) m\u00fccadele etmek i\u00e7in ya\u011f\u0131n hipermobilitesi meydana gelir ve bu da reaktif oksijen t\u00fcrlerinin (ROS) a\u015f\u0131r\u0131 \u00fcretimine yol a\u00e7ar. Hiperlipidemi ayr\u0131ca do\u011fum sonras\u0131 d\u00f6nemde esterle\u015fmemi\u015f ya\u011f asitleri (NEFA) ve \u03b2-hidroksib\u00fctirik asit (BHB) konsantrasyonlar\u0131n\u0131 da artt\u0131r\u0131r. Ayr\u0131ca memede h\u00fccresel solunum yoluyla oksijenin a\u015f\u0131r\u0131 kullan\u0131m\u0131, anormal oksidatif stres (OS) \u00fcretimine neden olur. Oksidatif stres, s\u00fct ineklerinin do\u011fum s\u0131ras\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131klar\u0131n\u0131 ve antiinflamatuar etkinliklerini bozar ve mastitise duyarl\u0131l\u0131klar\u0131n\u0131 art\u0131r\u0131r. Oksidatif stresi ve ard\u0131ndan gelen mastiti azaltmak i\u00e7in s\u00fct ineklerine harici bir kaynaktan antioksidanlar eklenir. S\u00fct ineklerinde ge\u00e7i\u015f d\u00f6neminde mastitisin azalt\u0131lmas\u0131 amac\u0131yla selenyum (Se) ile E ve B9 vitaminlerinin takviyesi konusunda kapsaml\u0131 \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015ft\u0131r.<\/p>

Yak\u0131n zamanda yap\u0131lan bir \u00e7al\u0131\u015fma, s\u00fct ineklerinde perinatal hastal\u0131klar\u0131n ana nedeninin oksidatif stres oldu\u011funu g\u00f6stermi\u015ftir. Benzer \u015fekilde ba\u015fka bir \u00e7al\u0131\u015fma, ROS'un a\u015f\u0131r\u0131 \u00fcretiminin, ge\u00e7i\u015f d\u00f6neminde s\u00fct ineklerinde ba\u011f\u0131\u015f\u0131kl\u0131k ve antiinflamatuar fonksiyonlar\u0131 bozan oksidatif strese neden oldu\u011funu bildirdi. Ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin bask\u0131lanmas\u0131 nedeniyle s\u00fct ineklerinin perinatal d\u00f6nemde mastitise duyarl\u0131l\u0131\u011f\u0131 artar. Tart\u0131\u015f\u0131ld\u0131\u011f\u0131 gibi, s\u00fct ineklerinde postpartum d\u00f6nemde oksidatif strese neden olan temel fakt\u00f6rler negatif enerji dengesi ve metabolik bozukluklard\u0131r. Bu nedenle \u00f6nceki tart\u0131\u015fmadan, hayvan\u0131n antioksidan kapasitesini artt\u0131rmada ve s\u00fct ineklerini ge\u00e7i\u015f d\u00f6neminde mastitise duyarl\u0131 hale getiren oksidatif stresi \u00f6nlemede beslenme y\u00f6netiminin en etkili yakla\u015f\u0131mlardan biri olabilece\u011fi sonucuna vard\u0131k.<\/p>

\"\"<\/figure><\/div>

Negatif enerji dengesi, s\u00fct ineklerinde do\u011fum s\u0131ras\u0131nda ya\u011f\u0131n hipermobilitesine neden olur, bu da NEFA ve ROS d\u00fczeylerinin artmas\u0131na neden olarak oksidatif strese yol a\u00e7ar. Oksidatif stres ayr\u0131ca anormal ba\u011f\u0131\u015f\u0131kl\u0131k reg\u00fclasyonunu ve iltihaplanmay\u0131 tetikleyerek s\u00fct ineklerini mastite yatk\u0131n hale getirir. Anormal ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi ve iltihaplanma ayn\u0131 zamanda lipid hipermobilitesine ve oksidatif strese yol a\u00e7arak TNF-a'n\u0131n a\u015f\u0131r\u0131 \u00fcretimini aktive eder.<\/p>

Genel olarak, s\u00fct ineklerinde do\u011fum sonras\u0131 d\u00f6nemin kritik oldu\u011fu ve onlar\u0131 mastitise yatk\u0131n hale getirdi\u011fi sonucuna vard\u0131k. Ge\u00e7i\u015f d\u00f6neminde s\u00fct ineklerinin mastitise duyarl\u0131l\u0131\u011f\u0131na yol a\u00e7an temel fakt\u00f6rler aras\u0131nda negatif enerji dengesi, ard\u0131ndan ya\u011f\u0131n hipermobilitesi, oksidatif stres ve bunun sonucunda anormal ba\u011f\u0131\u015f\u0131kl\u0131k reg\u00fclasyonu ve inflamasyon yer al\u0131r. Perinatal d\u00f6nemde s\u00fct inekleri baz\u0131 temel besin maddelerinde (E vitamini, folik asit ve selenyum) ciddi eksiklikler ya\u015far ve bu da onlar\u0131 mastitise yatk\u0131n hale getirir. Vitamin (E ve folik asit) ve Se takviyeleri, do\u011fum sonras\u0131 d\u00f6nemde s\u00fct ineklerinde ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesini olumlu y\u00f6nde etkiler ve oksidatif ve inflamatuar durumu azalt\u0131r. Bu nedenle ge\u00e7i\u015f d\u00f6neminde folik asit, selenyum ve E vitamini takviyelerinin s\u00fct ineklerinde mastitisin azalt\u0131lmas\u0131nda terap\u00f6tik bir takviye olarak de\u011ferlendirilebilece\u011fi \u00f6nerilmektedir.<\/p>

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[Kaynak: https:\/\/www.mdpi.com\/2076-3921\/11\/4\/657<\/a><\/p><\/div>","protected":false},"excerpt":{"rendered":"

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